2017年発表論文

2017-03-10

2017年発表論文

2016年発表論文

2017-03-10

2016年発表論文

  1. Hashimoto T, Chen L, Kimura H, Endler A, Koyama H, Miyata T *Shibasaki F, *Watanabe T. Silencing of eIF3e promotes blood perfusion recovery after limb ischemia through stabilization of hypoxia-inducible factor 2alpha activity. J Vasc Surg.64;1: 219-226, 2016(査読有)
  2. M. Hatano, *T. Migita, T. Ohishi, Y. Hasegawa, and F. Shibasaki: Disruption of Steroidogenic Factor 1 (SF-1/Ad4BP, NR5A1) Causes Lipid Accumulation in Leydig Cells via Suppression of StAR and CYP11A1. Endocrine 54:484-496, 2016(査読有)
  3. Kitakaze K, Tasakia C, Tajima Y, Hirokawa T, Tsujia D, *Sakuraba H, Itoh K. Combined replacement effects of human modified β-hexosaminidase B and GM2 activator protein for GM2 gangliosidoses fibroblasts. Biochemisty and Biophysics Reports, 7: 157-163, 2016.(査読有)
  4. D. Sadato, T. Ono, N. Kajiwara, N. Nomura, M. Ukaji, L. Yang, Y. Nishito, K. Sakimura, Y. Tajima, K. Oboki, and *F. Shibasaki. The e Subunit of Eukaryote Initiation Factor (eIF3e) is Required for Embryonic Development by Stabilizing eIF3 complex. (投稿中)
  5. F. Endo, T. Tabata, D. Sadato, M. Kawamura, N. Ando, *K. Oboki, M. Ukaji, K. Kobayashi, Y. Kobayashi, T. Ikeda, and *F. Shibasaki: Development of a Simple and Quick Immunochromatography Method for Detection of anti-HPV-16/-18 Antibodies. (投稿中)
  6. *T. Migita, A. Ueda, T. Ohishi, M. Hatano, H. Seimiya, S. Horiguchi, F. Koga, and F. Shibasaki: Epithelial-mesenchymal transition 1 promotes SOX2 and Nanog expression in bladder cancer. (投稿中)

2015年発表論文

2017-03-10

2015年発表論文

  1. A. En
  2. Funaki S, Nakamura T, Nakatani T, Umehara H, Nakashima H, Okumura M, Oboki K, Matsumoto K, Saito *H, Nakano T. Global DNA hypomethylation coupled to cellular transformation and metastatic ability FEBS Letters, 2015;589:4053-4060.(査読有)
  3. Osawa Y, Oboki K, Imamura J, Kojika E, Hayashi Y, Saibara T, Shibasaki F, Kohara M, *Kimura K. Inhibition of cAMP-response element-binding protein (CREB)-binding protein (CBP)/β-catenin reduces liver fibrosis in mice. EBioMedicine, 2015; 2(11): 1751-58 (査読有)
  4. Akagi Y, Imamura K, Kouno T, Nomura S, Kage S, Ema M, Nishijima N, Yamamoto K, Migita T, *Shibasaki F. Rapid Quantitative Detection by Real-Time Polymerase Chain Reaction with a Polymer Chip. Sensors and Materials. 27: 403, 2015(査読有)
  5. Nakano S, Tsukimura T, Togawa T, Ohashi T, Kobayashi M, Takayama K, Kobayashi Y, Abiko H, Satou M, Nakahata T, Warnock DG, Sakuraba H, *Shibasaki F. Rapid Immunochromatographic Detection of Serum Anti-alpha-Galactosidase A Antibodies in Fabry Patients after Enzyme Replacement Therapy. PLoS One. 10(6):e0128351, 2015(査読有)
  6. Sakurai A, Takayama K, Nomura N, Kajiwara N, Okamatsu M, Yamamoto N, Tamura T, Yamada J, Hashimoto M, Sakoda Y, Suda Y, Kobayashi, Kida H, *Shibasaki F. Fluorescent immunochromatography for rapid and sensitive typing of seasonal influenza viruses. PLoS One. 10(2):e0116715, 2015.(査読有)
  7. Gocho Y, Kiyokawa N, Ichikawa H, Nakabayashi K, Osumi T, Ishibashi T, Ueno H, Terada K, Oboki K, Sakamoto H, Shioda Y, Imai M, Noguchi Y, Arakawa Y, Kojima Y, Toyama D, Hata K, Yoshida T, Matsumoto K, Kato M, Fukushima T, Koh K, Manabe A, *Ohara A. A novel recurrent EP300-ZNF384 gene fusion in B-cell precursor acute lymphoblastic leukemia. Leukemia. doi: 10.1038/leu.2015.111. in press, 2015.(査読有)
  8. Endo Y, Hirahara K, Iinuma T, Shinoda K, Tumes DJ, Asou HK, Matsugae N, Obata-Ninomiya K, Yamamoto H, Motohashi S, Oboki K, Nakae S, Saito H, Okamoto Y, *Nakayama T. The Interleukin-33-p38 Kinase Axis Confers Memory T Helper 2 Cell Pathogenicity in the Airway. Immunity. 42:294-308, 2015. (査読有)
  9. Morita H, Arae K, Unno H, Miyauchi K, Toyama S, Nambu A, Oboki K, Ohno T, Motomura K, Matsuda A, Yamaguchi S, Narushima S, Kajiwara N, Iikura M, Suto H, McKenzie AN, Takahashi T, Karasuyama H, Okumura K, Azuma M, Moro K, Akdis CA, Galli SJ, Koyasu S, Kubo M, Sudo K, Saito H, Matsumoto K, *Nakae S. An Interleukin-33-Mast Cell-Interleukin-2 Axis Suppresses Papain-Induced Allergic Inflammation by Promoting Regulatory T Cell Numbers. Immunity. 43:175-86, 2015. (査読有)

2014年発表論文

2017-03-10

2014年発表論文

  1. A. Endler, L. Chen and *F. Shibasaki. Coactivator recruitment of AhR/ARNT1. Int J Mol Sci. 2014;15:11100-10. doi: 10.3390/ijms150611100.
  2. Sakurai A, Takayama K, Nomura N, Yamamoto N, Sakoda Y, Kobayashi, Y., Kida, H. and *Shibasaki, F. Multi-colored immunochromatography using nanobeads for rapid and sensitive typing of seasonal influenza viruses. J Virol Methods 209: 62-68, 2014(査読有)
  3. Ogiwara H, Yasui F, Munekata K, Takagi-Kamiya A, Munakata T, Nomura N, Shibasaki F, Kuwahara K, Sakaguchi N, Sakoda Y, Kida H and *Kohara, M. Histopathological evaluation of the diversity of cells susceptible to H5N1 virulent avian influenza virus. Am J Pathol 184: 171-183, 2014(査読有)
  4. Kobayashi K, Mitsui K, Ichikawa H, Nakabayashi K, Matsuoka M, Kojima Y, Takahashi H, Iijima K, Ootsubo K, Oboki K, Okita H, Yasuda K, Sakamoto H, Hata K, Yoshida T, Matsumoto K, *Kiyokawa N, *Ohara A. ATF7IP as a novel PDGFRB fusion partner in acute lymphoblastic leukaemia in children. Br J Haematol. 165: 836-41, 2014(査読有)
  5. E. Inage K. Kasakura T. Yashiro R. Suzuki Y. Baba M. Hara K. Oboki K. Matsumoto H. Saito F. Niyonsaba, Y. Ohtsuka, H Ogawa, K Okumura, T Shimizu, and *Nishiyama C. Critical roles for PU.1, GATA1 and GATA2 in the expression of human FcεRI on mast cells: PU.1 and GATA1 transactivate FCER1A, and GATA2 transactivates FCER1A and MS4A2. J Immunol. 192: 3936-46, 2014(査読有)
  6. Masuzawa A, Kiyotani C, Osumi T, Shioda Y, Iijima K, Tomita O, Nakabayashi K, Oboki K, Yasuda K, Sakamoto H, Ichikawa H, Hata K, Yoshida T, Matsumoto K, *Kiyokawa N, *Mori T. Poor responses to tyrosine kinase inhibitors in a child with precursor B-cell acute lymphoblastic leukemia with SNX2-ABL1 chimeric transcript. Eur J Haematol. 92: 263-7, 2014(査読有)
  7. Mashima T, Soma-Nagae T, Migita T, Kinoshita R, Iwamoto A, Yuasa T, Yonese J, Ishikawa Y, *Seimiya H. TRIB1 supports prostate tumorigenesis and tumor-propagating cell survival by regulation of endoplasmic reticulum chaperone expression. Cancer Res. 74(17):4888-97. 2014(査読有)
  8. *Migita T, Okabe S, Ikeda K, Igarashi S, Sugawara S, Tomida A, Soga T, Taguchi R, Seimiya H. Inhibition of ATP citrate lyase induces triglyceride accumulation with altered fatty acid composition in cancer cells. Int J Cancer. ;135(1):37-47. 2014(査読有)
  9. Ohishi T, Muramatsu Y, Yoshida H, *Seimiya H. TRF1 ensures the centromeric function of Aurora-B and proper chromosome segregation. Mol Cell Biol. 34(13):2464-78. 2014(査読有)

2013年発表論文

2017-03-10

2013年発表論文

  1. A. Endler, L. Chen, Q. Li, K. Uchida, T. Hashimoto, L. Lu, G. T. Xu and F. Shibasaki. "Int6/eIF3e silenced HIF2alpha stabilization enhances migration and tube formation of HUVECs via IL-6 and IL-8 signaling." Cytokine 62(1): 115-122, 2013. (査読有)
  2. S. Hasan, J. Dong, Y. Hara, Y. Morizane, F. Shibasaki and H. Ueda. "Protein-based open sandwich immuno-PCR for sensitive detection of small biomarkers." Anal Sci 29(9): 871-876, 2013. (査読有)
  3. R. Miyashita, L. Chen, Y. Morizane, Y. Takeshita, H. Fukui, T. Ishizaki, K. Hatakeyama, K. Ohseto, F. Shibasaki and H. Uchino. "Cytokine marker measurement in human neuroblastoma cells with supersensitive and multiplex assay: MUSTag technology." Acta Neurochir Suppl 118: 317-320, 2013. (査読有)
  4. S.Nakano, Y. Morizane, N. Makisaka, T. Suzuki, T. Togawa, T. Tsukimura, I. Kawashima, H. Sakuraba and F. Shibasaki. "Development of a Highly Sensitive Immuno-PCR Assay for the Measurement of alpha-Galactosidase A Protein Levels in Serum and Plasma." PLoS One 8(11): e78588, 2013. (査読有)
  5. H. Ogiwara, F. Yasui, K. Munekata, A. Takagi-Kamiya, T. Munakata, N. Nomura, F. Shibasaki, K. Kuwahara, N. Sakaguchi, Y. Sakoda, H. Kida and M. Kohara. "Histopathological Evaluation of the Diversity of Cells Susceptible to H5N1 Virulent Avian Influenza Virus." Am J Pathol. S0002-9440(13)00681-0, 2013. (査読有)
  6. Tanaka A, Jung K, Matsuda A, Jang H, Kajiwara N, Amagai Y, Oida K, Ahn G, Ohmori K, Kang KG, Matsuda H.: Daily intake of Jeju groundwater improves the skin condition of the model mouse for human atopic dermatitis. J Dermatol. 40(3): 193-200, 2013. (査読有)
  7. Ohmori K, Nishikawa S, Oku K, Oida K, Amagai Y, Kajiwara N, Jung K, Matsuda A, Tanaka A, Matsuda H.: Circadian rhythms and the effect of glucocorticoids on expression of the clock gene period1 in canine peripheral blood mononuclear cells. Vet J. 196(3): 402-407, 2013. (査読有)
  8. Akira Sakurai, Katsuyoshi Takayama, Namiko Nomura, Tsubasa Munakata, Naoki Yamamotod, Tsuruki Tamura, Jitsuho Yamada, Masako Hashimoto, Kazuhiko Kuwahara, Yoshihiro Sakoda, Yoshihiko Suda, Yukuharu Kobayashi, Nobuo Sakaguchi, Hiroshi Kida, Michinori Kohara, Futoshi Shibasaki Broad-Spectrum Detection of H5 Subtype Influenza A Viruses with a New Fluorescent Immuno-chromatography System. PLoS ONE 8(11): e76753, 2013(査読有)
  9. Dong J, Sakurai A, Nomura N, Park EY, Shibasaki F, Ueda H: Isolation of recombinant phage antibodies targeting the hemagglutinin cleavage site of highly pathogenic avian influenza virus. PLoS One. 8(4): e61158, 2013.(査読有)
  10. Kamijo S, Takeda H, Tokura T, Suzuki M, Inui K, Hara M, Matsuda H, Matsuda A, Oboki K, Ohno T, Saito H, Nakae S, Sudo K, Suto H, Ichikawa S, Ogawa H, Okumura K, Takai T. IL-33-Mediated Innate Response and Adaptive Immune Cells Contribute to Maximum Responses of Protease Allergen-Induced Allergic Airway Inflammation. J Immunol. 190(9):4489-4499, 2013(査読有)
  11. Hirashima K, Migita T, Sato S, Muramatsu Y, Ishikawa Y, Seimiya H.: Telomere length influences cancer cell differentiation in vivo. Mol Cell Biol. 33:2988-2995, 2013(査読有)
  12. Migita T, Okabe S, Ikeda K, Igarashi S, Sugawara S, Tomida A, Taguchi R, Soga T, Seimiya H.: Inhibition of ATP citrate lyase induces an anticancer effect via reactive oxygen species: AMPK as a predictive biomarker for therapeutic impact. Am J Pathol. 182:1800-1810, 2013. (査読有)
  13. Kasahara K*, Kaneda M, Miki T, Iida K, Sekino-Suzuki N, Kawashima I, Suzuki H, Shinohara M, Arai M, Ohno-Iwashita Y, Kojima S, Abe M, Kobayashi T, Okazaki T, Souri M, Ichinose A, Yamamoto N.: Clot retraction is mediated by factor XIII-dependent fibrin-IIb-myosin. Blood. 122(19):3340-3348, 2013. (査読有)

2012年発表論文

2017-03-10

2012年発表論文

  1. A. Endler, L. Chen, J. Zhang, G. T. Xu and F. Shibasaki. "Binding of the ERalpha and ARNT1 AF2 domains to exon 21 of the SRC1 isoform SRC1e is essential for estrogen- and dioxin-related transcription." J Cell Sci 125(Pt 8): 2004-2016, 2012. (査読有)
  2. R. Miyashita, L. Chen, H. Oshiro, H. Uchino and F. Shibasaki. "Int6 silencing causes induction of angiogenic factors in neuronal cells via accumulation of hypoxia-inducible factor 2alpha and decreases brain damage in rats." Neurosci Lett 528(1): 83-88, 2012. (査読有)
  3. Suzukawa M, Morita H, Nambu A, Arae K, Shimura E, Shibui A, Yamaguchi S, Suzukawa K, Nakanishi W, Oboki K, Kajiwara N, Ohno T, Ishii A, Körner H, Cua DJ, Suto H, Yoshimoto T, Iwakura Y, Yamasoba T, Ohta K, Sudo K, Saito H, Okumura K, Broide DH, Matsumoto K, Nakae S.: Epithelial cell-derived IL-25, but not Th17 cell-derived IL-17 or IL-17F, is crucial for murine asthma. J Immunol. 189(7): 3641-3652, 2012. (査読有)
  4. Matsuda A, Tanaka A, Pan W, Okamoto N, Oida K, Kingyo N, Amagai Y, Xia Y, Jang H, Nishikawa S, Kajiwara N, Ahn G, Ohmori K, Matsuda H.: Supplementation of the fermented soy product ImmuBalance™ effectively reduces itching behavior of atopic NC/Tnd mice. J Dermatol Sci. 67(2): 130-139, 2012. (査読有)
  5. Morita H, Arae K, Ohno T, Kajiwara N, Oboki K, Matsuda A, Suto H, Okumura K, Sudo K, Takahashi T, Matsumoto K, Nakae S.: ST2 requires Th2-, but not Th17-, type airway inflammation in epicutaneously antigen- sensitized mice. Allergol Int. 61(2): 265-273, 2012. (査読有)
  6. Sawaguchi M, Tanaka S, Nakatani Y, Harada Y, Mukai K, Matsunaga Y, Ishiwata K, Oboki K, Kambayashi T, Watanabe N, Karasuyama H, Nakae S, Inoue H, Kubo M. Role of Mast Cells and Basophils in IgE Responses and in Allergic Airway Hyperresponsiveness. J Immunol. 188(4):1809-1818, 2012.(査読有)
  7. Togawa T, Tsukimura T, Kodama T, Tanaka T, Kawashima I, Saito S, Ohno K, Fukushige T, Kanekura T, Satomura A, Kang DH, Lee BH, Yoo HW, Doi K, Noiri E, Sakuraba H.: Fabry disease: Biochemical, pathological and structural studies of the α-galactosidase A with E66Q amino acid substitution Mol Genet Metab 105:615-620, 2012. (査読有)
  8. Tsukimura T, Kawashima I, Togawa T, Kodama T, Suzuki T, Watanabe T, Chiba Y, Jigami Y, Fukushige T, Kanekura T, Sakuraba H.: Efficient uptake of recombinant α-galactosidase A produced with a gene-manipulated yeast by Fabry mice kidneys. Mol Med 18:76-82, 2012. (査読有)

2011年発表論文

2017-03-10

2011年発表論文

  1. Higashimura Y, Nakajima Y, Yamaji R, Harada N, Shibasaki F, Nakano Y, Inui H.: Up-regulation of glyceraldehyde-3-phosphate dehydrogenase gene expression by HIF-1 activity depending on Sp1 in hypoxic breast cancer cells. Arch Biochem Biophys. 509:1-8. 2011.
  2. Hansson MJ, Morota S, Chen L, Matsuyama N, Suzuki Y, Nakajima S, Tanoue T, Omi A, Shibasaki F, Shimazu M, Ikeda Y, Uchino H, Elmér E.: Cyclophilin D-sensitive mitochondrial permeability transition in adult human brain and liver mitochondria. J Neurotrauma. 28:143-53, 2011
  3. M.Kawakita,K. Hiramatsu,M.Yanagiya,Y.Doi,M.Kosaka:Determination of N1, N12-Diacetylspermine in Urine: A Novel Tumer Marker Methods Molec Biol 720 367-378, 2011
  4. Sakurai A, Nomura N, Nanba R, Sinkai T, Iwaki T, Obayashi T, Hashimoto K, Hasegawa M, Sakoda Y, Naito A, Morizane Y, Hosaka M, Tsuboi K, Kida H, Kai A, Shibasaki F Rapid typing of influenza viruses using super high-speed quantitative real-time PCR. J Virol Methods. 2011 Dec;178(1-2):75-81.
  5. Tsukimura T, Kawashima I, Togawa T, Kodama T, Suzuki T, Watanabe T, Chiba Y, Jigami Y, Fukushige T, Kanekura T, Sakuraba H.: Efficient uptake of recombinant α-galactosidase A produced with a gene-manipulated yeast by Fabry mice kidneys. Mol Med. 2011 Oct 21. [Epub ahead of print]
  6. Tsuji D, Akeboshi H, Matsuoka K, Yasuoka H, Miyasaki E, Kasahara Y, Kawashima I, Chiba Y, Jigami Y, Taki T, Sakuraba H, Itoh K.: Highly phosphomannosulated enzyme replacement therapy for GM2 gangliosidosis. Ann Neurol. 2011, 69(4):691-701
  7. Y. Tajima, S. Saito, K. Ohno, T. Tsukimura, S. Tsujino, H. Sakuraba: Biochemical and structural study on a S529V mutant acid α-glucosidase responsive to pharmacological chaperones. J. Hum. Genet., 56, 440-446, 2011
  8. T. Tsukimura, Y. Chiba, K. Ohno, S. Saito, Y. Tajima, H. Sakuraba: Molecular mechanism for stabilization of a mutant a-galactosidase A involving M51I amino acid substitution by iminosugars. Mol. Genet. Metab., 103, 26-32, 2011

2010年発表論文

2017-03-10

2010年発表論文

  1. Chen L., Endler A., Uchida K., Horiguchi S., Morizane Y., Iijima O., Toi M., Shibasaki F.: Int6/eIF3e silencing promotes functional blood vessel outgrowth and enhances wound healing by upregulating hypoxia-induced factor 2a expression. Circulation 122: 910-919, 2010
  2. Kim NH, Jung HJ, Shibasaki F, Kwon HJ.: NBBA, a synthetic small molecule, inhibits TNF-alpha-induced angiogenesis by suppressing the NF-kappaB signaling pathway.  Biochem. Biophys. Res. Commun. 391,1500-1055, 2010
  3. Zhu C, Hallin U, Ozaki Y, Grandér R, Gatzinsky K, Bahr BA, Karlsson JO, Shibasaki F, Hagberg H, Blomgren K.: Nuclear translocation and calpain-dependent reduction of Bcl-2 after neonatal cerebral hypoxia-ischemia. Brain Behav Immun. 24,822-830, 2010
  4. Shimada H., Ochi T., Imasato A., Morizane Y., Hori M., Ozaki H., Shinjo K.: Gene expression profiling and functional assays of activated hepatic stellate cells suggest that myocardin has a role in activation. Liver Int. 30: 42-54, 2010
  5. Togawa T*, Kawashima I*, Kodama T, Tsukimura T, Suzuki T, Fukushige T, Kanekura T, Sakuraba H. (* equally contributed): Tissue and plasma globotriaosylsphingosine could be a biomarker for assessing enzyme replacement therapy for Fabry disease. Biochem Biophys Res Commun. 399,716-20, 2010.
  6. K.Samejima, K.Hiramatsu, K.Takahashi, M. Kawakita, M. Kobayashi, H.Tsumoto, * K. Kohda: Identification and determination of urinary acetylpolyamines in cancer patients by electrospray ionization and time-of-flight mass spectrometry. Analytical Biochemistry401, 22-29, 2010
  7. Y. Tajima, S. Saito, K. Ohno, T. Tsukimura, Seiichi Tsujino, H. Sakuraba: Biochemical and structural study on a S529V mutant acid a-glucosidase responsive to pharmacological chaperones. J Hum Genet. (in press)
  8. Tsuji D, Akeboshi H, Matsuoka K, Yasuoka H, Miyasaki E, Kasahara Y, Kawashima I, Chiba Y, Jigami Y, Taki T, Sakuraba H, Itoh K.: Neural cell-directed enzyme replacement ameliorates disease phenotypes of a mouse model of neurodegenerative GM2 gangliosidosis. Annals of Neurology, 2011 (in press)
  9. T. Tsukimura, Y. Chiba, K. Ohno, S. Saito, Y. Tajima, H. Sakuraba: Molecular mechanism for stabilization of a mutant a-galactosidase A involving M51I amino acid substitution by iminosugars. Mol. Genet. Metab. 2011 (in press)

2009年発表論文

2017-03-10

2009年発表論文

  1. Zhu C, Hallin U, Ozaki Y, Grandér R, Gatzinsky K, Bahr BA, Karlsson JO, Shibasaki F, Hagberg H, Blomgren K.: Nuclear translocation and calpain-dependent reduction of Bcl-2 after neonatal cerebral hypoxia–ischemia. Biochem. Brain Behav Immun 2009 Sep 24. [Epub ahead of print]
  2. Kim NH, Jung HJ, Shibasaki F, Kwon H; NBBA, a synthetic small molecule, inhibits TNF-α-induced angiogenesis by suppressing the NF-kB signaling pathway. Biochem. Brain Res. Comm. 2009 Dec. 30. [Epub ahead of print]
  3. Chen L, Endler A, Shibasaki F.: Hypoxia and Angiogenesis: Regulation of Hypoxia-Inducible Factors via Novel Binding Factors (Review Article) Exp. Mol. Med. 27, 2009 Nov. [Epub ahead of print]
  4. Sakuma T, Sakurai A, Yasuda J.: Dimerization of tetherin is not essential for its antiviral activity against Lassa and Marburg viruses. PLoS One. 2009 Sep 9; 4(9):e6934.
  5. Tajima Y, Kawashima I, Tsukimura T, Sugawara K, Kuroda M, Suzuki T, Togawa T, Chiba Y, Jigami Y, Ohno K, Fukushige T, Kanekura T, Itoh K, Ohashi T, Sakuraba H.: Use of a modified α-N-acetylgalactosaminidase in the development of enzyme replacement therapy for Fabry disease. Am. J. Hum. Genet. 85, 569-580, 2009 Featured Article
  6. Sugawara K, Saito S, Sekijima M, Ohno K, Tajima Y, Kroos MA. AJJ. Reuser, Sakuraba H.: Structural modeling of mutant α-glucosidase resulting in a processing/transport defect in Pompe disease. J Hum Genet. 54, 324-330, 2009
  7. Sugawara K, Tajima Y, Kawashima I, Tsukimura T, Saito S, Ohno K, Iwamoto K, Kobayashi T, Itoh K, Sakuraba H.: Molecular interaction of imino sugars with human α-galactosidase: insight into the mechanism of complex formation and pharmacological chaperone action in Fabry disease. Mol. Genet. Metab. 96, 233-238, 2009
  8. Kanagawa M, Nishimoto A, Chiyonobu T, Takeda S, Miyagoe-Suzuki Y, Wang F, Fujikake N, Taniguchi M, Lu Z, Tachikawa M, Nagai Y, Tashiro F, Miyazaki J, Tajima Y, Takeda S, Endo T, Kobayashi K, Campbell K.P, Toda T.: Residual laminin-binding activity and enhanced dystroglycan glycosylation in novel model mice to dystroglycanopathy. Hum. Mol. Genet., 18, 621-631, 2009
  9. Chen L, Endler A, Uchida K, Horiguchi S, Morizane Y, Iijima O, Toi M, and Shibasaki F: Int6/eIF3e Silencing Promotes Functional Blood Vessel Outgrowth and Enhances Wound Healing by Upregulating HIF2Expression. Circulation (under revision)
  10. Tsuji D. Akeboshi H. Matsuoka K. Yashuoka H. Miyasaki E. Kasahara Y. Kawashima I. Chiba Y. Jigami Y. Taki T. Sakauraba H. Itoh K.: Neural cell-directed enzyme replacement ameliorates disease phenotypes of a mouse model of neurodegenerative GM2 gangliosidosis. J. Clinic. Invest. submitted.
  11. Morizane, Y., Yamada, Y., Makisaka, N., Ishikawa, Y., Takagi, M., Tajima, Y., Kawashima, I., Sakuraba, H., Endo, F. and Shibasaki, F.: Diagnosis of Fabry’s Disease with a Modified Immuno-PCR (MUSTag) Assay ofα-galactosidase A Protein from Spotted Whole Blood on Filter Paper. Under submission

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2008年発表論文

2017-03-10

2008年発表論文

  1. Futoshi Shibasaki, Li Chen, Kazuyo Uchida, Alexander Endler: Int6 as a novel regulator of normal vessel formation through hypoxia inducible factor 2 alpha. (Review Article) Exp. Mol. Med in press
  2. K. Sugawara, Y. Tajima, I. Kawashima, T. Tsukimura, S. Saito, K. Ohno, K. Iwamoto, T. Kobayashi, K. Itoh, H. Sakuraba: Molecular interaction of imino sugars with human α-galactosidase: insight into the mechanism of complex formation and pharmacological chaperone action in Fabry disease. Mol. Genet. Metab. in press.
  3. Sansson M, Teilum M, Saori Morota, Hiroyuki Uchino, Eskil Elmer. Neurobiol Dis 2008 in press
  4. M. Kanagawa, A Nishimoto, T. Chiyonobu, S. Takeda, Y. Miyagoe-Suzuki, F. Wang, N. Fujikake, M. Taniguchi, Z. Lu, M Tachikawa, Y. Nagai, F. Tashiro, J. Miyazaki, Y. Tajima, S. Takeda, T. Endo, K. Kobayashi, K. P. Campbell, T. Toda: Residual laminin-binding activity and enhanced dystroglycan glycosylation in novel model mice to dystroglycanopathy. Hum. Mol. Genet. Advance Access published on November 18, 2008.
  5. Uchino H, Kuroda Y, Morota S, Hirabayashi G, Ishii N, Shibasaki F, Ikeda Y, Hansson MJ, Elmér E. Probing the molecular mechanisms of neuronal degeneration: importance of mitochondrial dysfunction and calcineurin activation. J Anesth. 22, 253-62, 2008
  6. Tsukimura T. Tajima Y. Kawashima I. Fukushige T. Kanzaki T. Kanekura T. Ikekita M. Sugawara K. Suzuki T. Togawa T. Sakuraba H.: Uptake of recombinant human alpha-L-Iduronidase (laronisade) by cultured fibroblasts and Osteoblasts. Biol. Pharm. Bull. 2008 Sep; 31, 1691-1695.
  7. Yoshimizu M. Tajima Y. Matsuzawa F. Aikawa S. Iwamoto K. Kobayashi T. Edmunds T. Fujishima K. Itoh K. Ikekita M. Kawashima I. Sugawara K. Ohyanagi N. Suzuki T. Togawa T. Ohno K. Sakuraba H. : Binding parameters and thermodynamics of the interaction of imino sugars with a recombinant human acid alpha-glucosidase (alglucosidase alpha): insight into the complex formation mechanism. Clin. Chim. Acta. 391, 68-73, 2008
  8. Ariga T. Suetake K. Nakane M. Kubota M. Usuki S. Kawashima I. Yu RK. : Glycosphingolipid antigens in neural tumor cell lines and anti-glycosphingolipid antibodies in sera of patients with neural tumors. Neurosignals. 16, 226-234, 2008
  9. Li Chen, Kazuyo Uchida, Alexander Endler, Shin-ichiro Horiguchi, Masakazu Toi and Futoshi Shibasaki. Int6/HIF2a Acts as A Master Switch for Inducing Normal Neovessels in Adult Mice 2008 (submitting)
  10. Li Chen, Alexander Endler, Yoshihito Morizane, Kazuyo Uchida, and Futoshi Shibasaki. Int6 silencing induce several angiogenic factor production mediated by HIF2 in endothelial cells 2008 (submitting)
  11. Li Chen, Alexander Endler, Kazuyo Uchida, and Futoshi Shibasaki. Adenylate kinase-1(AK1); kinetic behavior is relationship with HIF2 both in hypoxia and in normoxia BBRC 2008 (submitting )
  12. Y, Morizane, Y, Yamada, S, Ishikawa, N, Makisaka, Y, Komata, M., Takagi, Y. Tajima, I. Kawashima, H. Sakuraba and F, Shibasaki: Supersensitive Multiple Screening Assay for Fabry Disease. (submitting)
  13. A., Endler, L., Chen and F., Shibasaki: Splice variant of ARNT 1.1 and SRC1e reveal novel transcriptional regulations related to TCDD and estrogen receptor response (submitting) 2008


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2007年発表論文

2017-03-10

2007年発表論文

  1. Li Chen, Kazuyo Uchida, Alexander Endler, and Futoshi Shibasaki: Mammalian Tumor Suppressor Int6 Specifically Targets HIF-2To Degradation by Hypoxia- And pVHL- Independent Regulation. J. Biol. Chem. 282. 12707-12716, 2007
  2. Hirata T, Cui YJ, Funakoshi T, Mizukami Y, Ishikawa YI, Shibasaki F, Matsumoto M, Sakabe T.: The temporal profile of genomic responses and protein synthesis in ischemic tolerance of the rat brain induced by repeated hyperbaric oxygen. Brain Res. 1, 214-222, 2007
  3. I. Kawashima, K. Watabe, Y. Tajima, T. Fukushige, T. Kanzaki, T. Kanekura, K. Sugawara, N. Ohyanagi, T. Suzuki, T. Togawa, H. Sakuraba: Establishment of immortalized Schwann cells from Fabry mice and their low uptake of recombinant α-galactosidase. J Hum Genet. 2007; [Epub ahead of print]
  4. Y. Tajima, F. Matsuzawa, SI. Aikawa SI, T. Okumiya, M. Yoshimizu, T. Tsukimura, M. Ikekita, S. Tsujino, A. Tsuji, T. Edmunds, H. Sakuraba: Structural and biochemical studies on Pompe disease and a "pseudodeficiency of acid alpha-glucosidase". J Hum Genet. 2007 Sep 6; [Epub ahead of print]
  5. H. Akeboshi, Y. Chiba, Y. Kasahara, M. Takashiba, Y. Takaoka, M. Ohsawa, Y. Tajima, I. Kawashima, D. Tsuji, K. Itoh, H. Sakuraba, Y. Jigami.: Production of recombinant beta-hexosaminidase A, a potential enzyme for replacement therapy for Tay-Sachs and Sandhoff diseases, in the methylotrophic yeast Ogataea minuta. Appl Environ Microbiol. 73, 4805-4812, 2007.
  6. I. Kawashima, M. Ohsawa, T. Fukushige, Y. Nagayama, Y. Niida, M. Kotani, Y. Tajima, T. Kanekura, T. Kanzaki, H. Sakuraba: Cytochemical analysis of storage materials in cultured skin fibloblasts from patients with I-cell disease. Clinical Chimical Acta, 378, 142-146, 2007.
  7. Kawashima I, Watabe K, Tajima Y, Fukushige T, Kanzaki T, Kanekura T, Sugawara K, Ohyanagi N, Togawa T, Sakuraba H,: Establishment of immortalized Schwann cells from Fabry mice and their low uptake of recombinant-galactosidase. 2007; [Epub ahead of print]
  8. Tai T, Kawashima I, Ogura K.: Anticarbohydrate Antibody. Comprehesive Glycoscience. Editor-in Chief:J.P.Kamerling, The Netherlands, ELSEVIER, 2007, 3, 765-785
  9. Akeboshi H, Chiba Y, Kasahara Y, Takashiba M, Takaoka Y, Ohsawa M, Tajima Y, Kawashima I, Tsuji D, Itoh K, Sakuraba H, Jigami Y.: Production of recombinant beta-hexosaminidase A, a potential enzyme for replacement therapy for Tay-Sachs and Sandhoff diseases, in the methylotrophic yeast Ogataea minuta. Appl Environ Microbiol. 2007 Aug;73(15):4805-12.
  10. Kawashima I, Ohsawa M, Fukushige T, Nagayama Y, Niida Y, Kotani M, Tajima Y, Kanekura T, Kanzaki T, Sakuraba H.: Cytochemical analysis of storage materials in cultured skin fibroblasts from patients with I-cell disease. Clin Chim Acta. 2007 Mar;378(1-2):142-6.
  11. Spinal cord mitochondria display lower calcium retention capacity compared with brain mitochondria without inherent differences in sensitivity to cyclophilin D inhibition. Morota S, Hansson MJ, Ishii N, Kudo Y, Elmer E, Uchino H. J Neurochem. 2007 in press
  12. Re-evaluation of mitochondria as primary neuroprotective targets of minocycline Roland Mansson, Magnus Hansson, Saori Morota, Hiroyuki Uchino, Christine Ekdahl, Ekdahl Clementson, Eskil Elmer. Neurobiol Dis. 1:198-205 (2007)
  13. Calcium-induced generation of reactive oxygen species in brain mitochondria is mediated through permeability transition Magnus Hansson,M,Roland Mansson, Saori Morota, Hiroyuki Uchino, Kallur T, Sumi T, Ishii N, Shimazu M, Keep M, Jegorov A, Eskil Elmer. J Neurochem. 2007 in press
  14. Intramitochondrial pH links modulation of potassium conductance with the mitochondrial permeability transition-Implications for preconditioning and tolerance in cerebral ischemia. Hansson M, Teilum M, Saori Morota, Hiroyuki Uchino, Eskil Elmer. Neurobiol Dis 2008 in press


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2006年発表論文

2017-03-10

2006年発表論文

  1. Yamaguchi, T., Miyata, K., Shibasaki, F., Isshiki, A. & Uchino, H. Effect of cyclosporin a on immediate early gene in rat global ischemia and its neuroprotection. J Pharmacol Sci 100, 73-81 (2006).
  2. Uchino, H., Morota, S., Takahashi, T., Ikeda, Y., Kudo, Y., Ishii, N., Siesjo, B. K. & Shibasaki, F. A novel neuroprotective compound FR901459 with dual inhibition of calcineurin and cyclophilins. Acta Neurochir Suppl 96, 157-62 (2006).
  3. Ishikawa, Y., Uchino, H., Morota, S., Li, C., Takahashi, T., Ikeda, Y., Ishii, N. & Shibasaki, F. Search for novel gene markers of traumatic brain injury by time differential microarray analysis. Acta Neurochir Suppl 96, 163-7 (2006).
  4. Hallin, U., Kondo, E., Ozaki, Y., Hagberg, H., Shibasaki, F. & Blomgren, K. Bcl-2 phosphorylation in the BH4 domain precedes caspase-3 activation and cell death after neonatal cerebral hypoxic-ischemic injury. Neurobiol Dis 21, 478-86 (2006).


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2005年発表論文

2017-03-10

2005年発表論文

  1. Wang, Y., Shibasaki, F. & Mizuno, K. Calcium signal-induced cofilin dephosphorylation is mediated by Slingshot via calcineurin. J Biol Chem 280, 12683-9 (2005).
  2. Kondo, E., Miyake, T., Shibata, M., Kimura, T., Iwagaki, H., Nakamura, S., Tanaka, T., Ohara, N., Ichimura, K., Oka, T., Yanai, H., Shibasaki, F. & Yoshino, T. Expression of phosphorylated Ser70 of Bcl-2 correlates with malignancy in human colorectal neoplasms. Clin Cancer Res 11, 7255-7263 (2005).
  3. Wang, Y., Shibasaki, F. & Mizuno, K. Calcium signal-induced cofilin dephosphorylation is mediated by Slingshot via calcineurin. J Biol Chem 280, 12683-12689 (2005).
  4. Katanosaka, Y., Iwata, Y., Kobayashi, Y., Shibasaki, F., Wakabayashi, S. & Shigekawa, M. Calcineurin inhibits Na+/Ca2+ exchange in phenylephrine-treated hypertrophic cardiomyocytes. J Biol Chem 280, 5764-5772 (2005).
  5. Fujii, T., Onohara, N., Maruyama, Y., Tanabe, S., Kobayashi, H., Fukutomi, M., Nagamatsu, Y., Nishihara, N., Inoue, R., Sumimoto, H., Shibasaki, F., Nagao, T., Nishida, M. & Kurose, H. Galpha12/13-mediated production of reactive oxygen species is critical for angiotensin receptor-induced NFAT activation in cardiac fibroblasts. J Biol Chem 280, 23041-23047 (2005).


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2004年発表論文

2017-03-10

2004年発表論文


1. Kato H, Tamamizu-Kato S, and Shibasaki F.: Histon deacetylase 7 associates with hypoxia- inducible factor 1 alpha and regulate transcriptional activity. J. Biol. Chem. 274, 41966 ? 41974, 2004.

2. Tsukiyama-Kohara K, Tone S, Maruyama I, Inoue K, Katsume A, Nuriya H, Ohmori H, Ohkawa J, Taira K, Hoshikawa Y, Shibasaki F, Reth M, Minatogawa Y, Kohara M.: Activation of the CKI-CDK-Rb-E2F pathway in full genome hepatitis C virus-expressing cells. J. Biol. Chem. 279:14531-41, 2004.

3. Uchino H, Ishii N, and Shibasaki F.: Calcineurin and cyclophilin D are differential targets of neuroprotection by immunosuppressants CsA and FK506 in ischemic brain damage. Acta Neurochir Suppl. 86:105-111, 2004

4. Uchino H, Ishii N, Shibasaki F.: Calcineurin and cyclophilin D are differential targets of neuroprotection by immunosuppressants CsA and FK506 in ischemic brain damage. Acta Neurochir Suppl. 86:105-111, 2004



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2003年発表論文

2017-03-10

2003年発表論文


1. Tomida T, Hirose K, Takizawa A, Shibasaki F, Iino M.: NFAT functions as a working memory of Ca2+ signals in decoding Ca2+ oscillation. EMBO J. 22, 3825-32, 2003.

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2002年発表論文

2017-03-10

2002年発表論文


1. Yoshida H, Yoshizawa T, Shibasaki F, Shoji S, and Kanazawa I.: Chemical chaperones reduce aggregate formation and cell death caused by the truncated Machado-Joseph disease gene product with an expanded polyglutamine stretch. Neurobiol Dis.10:88-99, 2002

2. Nomura, T., Yamamoto, H., Mimata, H., Shitashige, M., Shibasaki, F., Mityamoto, E., and Nomura Y.; Enhancement by CsA of Taxol-induced apoptosis of human urinary bladder cancer cells. Urol. Res. 30, 102-111, 2002

3. Uchino, H., Minamikawa-Tachino, R., Kristi?n, T., Perkins, G., Narazaki, M., Siesj?, B.K., and Shibasaki, F. Differential neuroprotection by Cyclosporin A and FK506 following ischemia corresponds with differing abilities to inhibit calcineurin and the mitochondrial permeability transition. Neurobiol. Dis. 10, 219-233, 2002.

4. Omori N, Mizuguchi H, Ohsawa K, Kohsaka S, Hayakawa T, Abe K, and Shibasaki F.; Modification of a fiber protein in an adenovirus vector improves in vitro gene transfer efficiency to the mouse microglial cell line. Neurosci Lett. 324,145-148, 2002

5. Shinoura N, Sakurai S, Shibasaki F, Asai A, Kirino T, Hamada H; Co-transduction of Apaf-1 and caspase-9 highly enhances p53-mediated apoptosis in gliomas. Br. J. Cancer. 86, 587-95, 2002

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2001年発表論文

2017-03-10

2001年発表論文


1. Yoshimoto T, Uchino H, He QP, Li PA, Siesj? BK. Related Articles Cyclosporin A, but not FK506, prevents the downregulation of phosphorylated Akt after transient focal ischemia in the rat. Brain Res. 899,148-58, 2001.

2. Miyata, K., Omori, N., Uchino, H., Yamaguchi, T., Isshiki, A. and Shibasaki, F.: Brain derived neurotrophic factor/TrkB mediates the neuroprotective effect of cyclosporin A in forebrain ischemia. Neuroscience.105, 571-578. 2001

3. Shitashige, M., Toi, M., Yano, T., Shibata, M., Matsuo, Y., and Shibasaki, F.: Phosphorylation of serine 70 of Bcl-2 as a possible prognostic maker in breast cancer. J. Biochem. 130, 741-748, 2001

4. Machida, K., Tsukiyama-Kohara, K., Seike, E., Tone, S., Shibasaki, F., Shimizu, M., Takahashi, H., Hayashi, Y., Funata, N., Taya, C., et al. Inhibition of cytochrome c release in Fas-mediated signaling pathway in transgenic mice induced to express hepatitis C viral proteins. J. Biol. Chem. 276, 12140-12146, 2001.

5. Okamoto, K., Shinoura, N., Egawa, N., Asai, A., Kirino, T., Shibasaki, F., and Shitara, N. Adenovirus-mediated transfer of p53 augments hyperthermia-induced apoptosis in U251 glioma cells. Int. J. Radiat. Oncol. Biol. Phys. 50, 525-531, 2001.

6. Zou, Y., Hiroi, Y., Uozumi, H., Takimoto, E., Toko, H., Zhu, W., Kudoh, S., Mizukami, M., Shimoyama, M., Shibasaki, F., Nagai, R., Yazaki, Y., and Komuro, I. Calcineurin plays a critical role in the development of pressure overload-induced cardiac hypertrophy. Circulation 104, 97-101, 2001.

7. Zou, Y., Yao , A., Zhu, W., Kudoh, S., Hiroi, Y., Shimoyama, M., Uozumi, H., Kohmoto, O., Takahashi, T., Shibasaki, F., Nagai, R., Yazaki, Y., and Komuro, I. Isoproterenol activates extracellular signal-regulated protein kinases in cardiomyocytes through calcineurin. Circulation 104, 102-108, 2001.



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2000年発表論文

2017-03-10

2000年発表論文


1. Zhu, W., Zou, Y., Shiojima, I., Kudoh, S., Aikawa, R., Hayashi, D., Mizukami, M., Toko, H., Shibasaki, F., Yazaki, Y., Nagai, R., and Komuro, I. : Ca2+/calmodulin-dependent kinase II and calcineurin play critical roles in endothelin-1-induced cardiomyocyte hypertrophy. J. Biol. Chem. 275, 15239-15245, 2000.

2. Saito, S., Hiroi, Y., Zou, Y., Haruhiko, T., Shibasaki, F., Yazaki, Y., Nagai, R., and Komuro, I. : ?-adrenergic pathway induces apoptosis through calcineurin activation in cardiac myocytes. J. Biol. Chem. 275, 34528-34533, 2000.

3. Matsuda, S., Shibasaki, F., Takehana, K., Mori, H., Nishida, E. and Koyasu, S.: Two distinct action mechanisms of immunophilin-ligand complexes for the blockade of T-cell activation. EMBO letter 1, 428-434, 2000.

4. Simizu, S., Shibasaki, F. and Osada, H.: Bcl-2 inhibits calcineurin-mediated Fas ligand expression in antitumor drug-treated Baby Hamster Kidney cells. Jpn. J Cancer Res 91 706-714, 2000.

5. Zhu W, Zou Y, Shiojima I, Kudoh S, Aikawa R, Hayashi D, Mizukami M, Toko H, Shibasaki F, Yazaki Y, Nagai R, Komuro I. : Ca2+/calmodulin-dependent kinase II and calcineurin play critical roles in endothelin-1-induced cardiomyocyte hypertrophy. J. Biol. Chem. 275,15239-15245, 2000.

6. Omori, N., Hoshikawa, Y., Uchino, H., Shibasaki, F.: Nuclear factor of activated T-cells/ calcineurin pathway in microglia. Neurochem. Res. 25, 983-1066, 2000.

7. Yoshizawa T, Yamagishi Y, Koseki N, Goto J, Yoshida H, Shibasaki F, Shoji S, and Kanazawa I. : Cell cycle arrest enhances the in vitro cellular toxicity of the truncated Machado-Joseph disease gene product with an expanded polyglutamine stretch. Hum. Mol. Genetics 9, 69-78, 2000.


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1999年発表論文

2017-03-10

1999年発表論文


1. Shimoyama, M. Hayashi, D., Takimoto, E., Zou, Y., Oka, T. Uozumi, H., Kudou, S., Shibasaki, F., Yazaki, Y., Nagai, R., Komuro, I. : Calcineurin plays a critical role in pressure overloads-induced cardiac hypertrophy. Circulation 100, 2449-2454. 1999.

2. Wang, H-G., Pathan, N., Ethel, I. M., Krajewski, S., Yamaguchi, Y., Shibasaki, F., McKeon, F., Bobo, T., Franke, T. F., and Reed, J. C. : Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD. Science 284, 339-343. 1999.


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1998年以前発表論文

2017-03-10

1998年以前発表論文


1. Zhu J, Shibasaki F, Price R, Guillemot JC, Yano T, Dotsch V, Wagner G, Ferrara P, McKeon F. Intramolecular masking of nuclear import signal on NF-AT4 by casein kinase I and MEKK1. Cell 93 851-861, 1998.

2. Payne, J., Shibasaki, F., and Mercola, M.: Spina bifida occulta in homozygous Patch mouse embryos. Dev. Dyn. 209, 105-116, 1997.

3. Shibasaki, F., Kondo, E., Akagi, T., and McKeon, F.: Suppression of Signalling Through NF-AT by Interactions Between Calcineurin and Bcl-2. Nature 386, 728-731, 1997.

4. Shibasaki, F., Price, R., Milan , D., and McKeon, F.: Role of kinases and the phosphatase calcineurin in the nuclear shuttling of transcription factor NF-AT4. Nature 382. 370-373, 1996.

5. Shibasaki, F. and McKeon, F.: Calcineurin activated Ca2+-induced cell death in BHK cells. J. Cell Biol. 131. 735 ? 743, 1995.

6. Hirano N, Shibasaki F, Sakai R, Tanaka T, Nishida J, Yazaki Y, Takenawa T, and Hirai H.: Molecular cloning of the human glucose-regulated protein ERp57/GRP58, a thiol-dependent reductase. Identification of its secretory form and inducible expression by the oncogenic transformation. Eur. J. Biochem. 234, 336-342, 1995.

7. Shibasaki, F., Fukami, K., Fukui , Y. and Takenawa, T.: Phosphatidylinositol 3-kinase binds to ?-actinin through the p85 subunit. Biochem. J. 302, 551-557, 1994.

8. Hirano, N., Shibasaki, F., Kato, H., Sakai , R., Tanaka, T., Nishida, J., Yazaki, Y., Takenawa, T. and Hirai, H.: Molecular cloning and characterization of a cDNA for bovine phospholipase C-g Proposal of redesignation of phospholipase C-?g. Biochem. Biophys. Res. Commun. 204, 375-382, 1994.

9. Matuoka, K., Shibasaki, F., Shibata, M. and Takenawa, T.: Ash/Grb-2, a SH2/SH3-containing protein, couples to signaling for mitogenesis and cytoskeletal reorganization by EGF and PDGF. EMBO J. 12, 3467-3473, 1993.

10. Hayashi, H., Nishioka, Y., Kamohara, S., Kanai, F., Ishii, K., Fukui , Y., Shibasaki, F., Takenawa, T., Kido, H., Katsunuma, N. and Ebina, Y.: The a-type 85-kDa subunit of phosphatidylinositol 3-kinase is phosphorylated at tyrosines 368, 580, and 607 by the insulin receptor. J. Biol. Chem. 268, 7107-7117, 1993.

11. Nakanishi, O., Shibasaki, F., Hidaka, M., Homma, Y. and Takenawa, T.: Phospholipase C-g1 associates with viral and cellular src kinases. J. Biol. Chem. 268, 10754-10759, 1993.

12. Shibasaki, F., Fukui , Y. and Takenawa, T. (1993). Different properties of monomer and heterodimer forms of phosphatidylinositol 3-kinases. Biochem. J. 289, 227-231.

13. Hayashi, H., Kamohara, S., Nishioka, Y., Kanai, F., Miyake, N., Fukui , Y., Shibasaki, F., Takenawa, T. and Ebina, Y.: Insulin treatment stimulates the tyrosine phosphorylation of the ?-type 85-kDa subunit of phosphatidylinositol 3-kinase in vivo. J. Biol. Chem. 267, 22575-22580, 1992.

14. Kato, H., Fukami, K., Shibasaki, F., Homma, Y. and Takenawa, T.: Enhancement of phospholipase C- d 1 activity in the aortas of spontaneously hypertensive rats. J. Biol. Chem. 267, 6483-6487, 1992.

15. Tanaka, T., Shibasaki, F., Ishikawa, M., Hirano, N., Sakai , R., Nishida, J., Takenawa, T. and Hirai, H.: Molecular cloning of bovine actin-like protein, actin 2. Biochem. Biophys. Res. Commun. 187, 1022-1028, 1992.

16. Hayashi, H., Miyake, N., Kanai, F., Shibasaki, F., Takenawa, T. and Ebina, Y.: Phosphorylation in vitro of the 85 kDa subunit of phosphatidylinositol 3-kinase and its possible activation by insulin receptor tyrosine kinase. Biochem. J. 280, 769-775, 1991.

17. Shibasaki, F., Homma, Y. and Takenawa, T.: Two types of phosphatidylinositol 3-kinase from bovine thymus. Monomer and heterodimer form. J. Biol. Chem. 266, 8108-8114, 1991.

18. Homma, Y., Emori, Y., Shibasaki, F., Suzuki, K. and Takenawa, T.: Isolation and characterization of a g-type phosphoinositide-specific phospholipase C (PLC- g 2). Biochem. J. 269, 13-18, 1990.



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総説論文

2017-03-10

総説論文


1. Shibasaki, F, Uchino, H., Kristian, T., Perkins, G., Ishii, N., and Siesj?, B.K.: Potent neuroprotection of CsA by inhibiting pathways involving calcinenurn and cyclophilin D in forebrain ischemia. Pharmacology of Cerebral Ischemia (Medpharm Scientific Publisher Stuttgart ), 453-465, 2005

2. Siesj?, B. K., Uchino, H., Yoshimoto, T., Hu, B. and Shibasaki, F.: Mitochondrial dysfunction and maturation of brain damage after transient ischemia. Maturation Phenomenon in cerebral ischemia IV. Springer Velague U Ito (e.d.s) 2003 (in press).

3. Siesj?, B.K., Uchino, H., and Shibasaki, F.: Post-treatment in transient global and focal ischemia: New pharmacological avenues. Pharmacology of Cerebral Ischemia (Medpharm Scientific Publisher Stuttgart ), 2003 .

4. Shibasaki, F., Hallin, U., and Uchino, H.; Review: Calcineurin as a multifunctional regulator. J. Biochem. 131, 1-15, 2002

5. Siesjo, BK, Kristian, T., Shibasaki, F., and Uchino, H.: The role of mitochondrial dysfunction in reperfusion damage in the brain. Pharmacology of Cerebral Ischemia (Medpharm Scientific Publisher Stuttgart ), 163-175, 2000



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